1.      Walker, G.C., Kenyon, C., Bagg, A., Elledge, S.J., Perry, K. and Shanabruch, W. (1982) Regulation and Functions of Escherichia coli Genes Induced by DNA Damage.  In:  Molecular and Cellular Mechanisms of Mutagenesis, J.F. Lemontt and W.M. Generoso, eds., Plenum Press, New York, pp. 43-63.


2.      Walker, G.C., Elledge, S.J., Perry, K., Bagg, A. and Kenyon, C. (l982) Regulation and Function of Cellular Gene Products Involved in UV and Chemical Mutagenesis in E. coli.  In:  Induced Mutagenesis:  Molecular Mechanisms and Their Implications for Environmental Protection,  C.W. Lawrence, L. Prakash, and F. Sherman, eds., Plenum Press, New York, pp. 181-198.


3.      Perry, K., Elledge, S.J., Lichtman, M. and Walker, G.C. (1982) Plasmid-Mediated Enhancement of Mutagenesis.  In:  Environmental Mutagens and Carcinogens,   Proceedings of the Third International Conference on Environmental Mutagens, T. Sugimura, S. Kondo, and H. Takabe, eds., University of Tokyo Press, Tokyo, and Alan Liss, Inc., New York, pp.  113-120.


4.      Walker, G.C., Elledge, S.J., Kenyon, C., Krueger, J. and Perry, K. (1982) Mutagenesis and Other Responses Induced by DNA Damage in Escherichia coli. Biochemie 64:607-610.


5.      Krueger, J.H., Elledge, S.J. and Walker, G.C. (1983) Isolation of Tn5 Insertion Mutations in the lexA Gene of Escherichia coliJ. Bacteriol. 153:1368-1378.


6.      Elledge, S.J. and Walker, G.C. (1983) Proteins Required for UV and Chemical Mutagenesis:  Identification of the Products of the umuC Locus of Escherichia coliJ. Mol. Biol. 164:175-192.


7.      Elledge, S.J. and Walker, G.C. (1983) The muc Genes of pKM101 are Induced by DNA Damage.  J. Bacteriol. 155:1306-1315.


8.      Elledge, S.J., Perry, K., Krueger, J., Mitchell, B.B. and Walker, G.C. (1983) Cellular Components Required for Mutagenesis. In: Cellular Responses to DNA Damage, E. Friedberg and B. Bridges, eds., Academic Press, New York, pp. 353-361.


9.      Elledge, S.J.  (1983) Identification and Characterization of Genes Involved in Mutagenesis in Escherichia coli.   Doctoral Dissertation, Massachusetts Institute of Technology,  Cambridge, Massachusetts.


10.    Winans, S.C., Elledge, S.J., Mitchell, B.B., Marsh, L.  and Walker, G.C. (1985) Site Directed Insertion and Deletion Mutagenesis with Cloned Fragments in Escherichia coli. J. Bacteriol 161:1219-1221.


11.    Perry, K., Elledge, S.J., Mitchell, B.B, Marsh, L. and Walker, G.C. (1985) umuDC and mucAB Whose Products are Required for UV Light- and Chemical-induced Mutagenesis:  UmuD, MucA, and LexA Proteins Share Homology. Proc. Natl. Acad. Sci. USA 82:4331-4335.


12.    Elledge, S.J. and Walker, G.C. (1985) Phasmid Vectors for the Identification of Genes by Complementation of Escherichia coli Mutants.  J. Bacteriol. 162:777-783.


13.    Snyder, M., Elledge, S.J. and Davis, R.W. (1986) Rapid Mapping of Antigen Coding Regions and Creating Insertion Mutations in Yeast by mini-Tn10 Transplacon Mutagenesis. Proc. Natl. Acad. Sci. USA 83:730-734.


14.    Snyder, M., Elledge, S.J., Sweetser, D., Young, R.A. and Davis, R.W. (1987) lgt11: Gene Isolation with Antibody Probes and Other Applications.  Methods Enzymol. 154:107-128.


15.    Elledge, S.J. and Davis, R.W.  (1987)  Identification and Isolation of the Gene Encoding the Small Subunit of Ribonucleotide Reductase from Saccharomyces cerevisiae: A DNA Damage-Inducible Gene Required for Mitotic Viability. Mol. Cell. Biol. 7:2783-2793.


16.    Elledge, S.J. and Davis, R.W. (1988) A Family of Versatile Centromeric Vectors Designed for Use in the Sectoring Shuffle Mutagenesis Assay in Saccharomyces cerevisiaeGene 70:303-312.


17.    Elledge, S.J. and Davis, R.W.  (1989)  Position and Density Effects on Repression by Stationary and Mobile DNA-binding Proteins. Genes & Development 3:185-197.


18.    Elledge, S.J., Sugiono, P., Guarente, L. and Davis, R.W.  (1989)  A Genetic Selection for Genes Encoding Sequence-specific DNA-binding Proteins.  Proc. Natl. Acad. Sci. USA 86:3689-3693.


19.    Elledge, S.J. and Davis, R.W. (1989) DNA-damage Induction of Ribonucleotide Reductase. Mol. Cell. Biol. 9:4932-4940.


20.    Elledge, S.J. and Davis, R.W. (1989) Identification of the Damage Responsive Element of RNR2 and Evidence that Four Distinct Cellular Factors Bind It. Mol. Cell. Biol. 9:5373-5386.


21     Jasin, M., Elledge, S.J., Davis, R.W., and P. Berg. (1990) Gene Targeting at the Human CD4 Locus by Epitope Addition. Genes & Development 4:157-166.


22.    Elledge, S.J. and Davis, R.W. (1990) Two Genes Differentially Regulated in the Cell Cycle and by DNA-damaging Agents Encode Alternative Regulatory Subunits of Ribonucleotide Reductase. Genes & Dev. 4:740-751.


23.    Elledge, S.J., Mulligan, J., Ramer, S., Spottswood, M., and R.W. Davis. (1991) Lambda YES: A Multifunctional cDNA Expression Vector for the Isolation of Genes by Complementation of Yeast and E. coli Mutations. Proc. Natl. Acad. Sci. USA 88:1731-1734.


24.    Elledge, S. and Spottswood, M. (1991) A New Human p34 Protein Kinase, CDK2, Identified by Complementation of a cdc28 Mutation in Saccharomyces cerevisiae, is a Homolog of the Xenopus Eg1 gene. EMBO J. 10:2653-2659.


25.    Elledge, S. and Z. Zhou (1992) Cell cycle and DNA Damage Regulation of Ribonucleotide Reductase in Saccharomyces cerevisiae.  In: Induced Effects of Genotoxic Agents in Eukaryotic Cells ,  T. G. Rossman, ed., Hemisphere Publishing Corporation, Washington, D.C. pp. 65-80.


26.    Elledge, S.J., Richman, R., Hall, F.L., Williams, R.T., Lodgson, N. and Harper, J.W. (1992) CDK2 encodes a 33KDa cyclin A-associated protein kinase and is expressed prior to CDC2 in the cell cycle. Proc. Natl. Acad. Sci. USA 89:2907-2911.


27.    Elledge, S., Zhou, Z., and Allen, J. (1992) Ribonucleotide reductase: regulation, regulation, regulation. Trends Biochem. Sci. 17:119-123.


28.    Bellen, H.J., D’Evelyn, D.D., Harvey, M., and Elledge, S.J. (1992) Isolation of temperature-sensitive diptheria toxins in yeast and their effects on Drosophilia cells. Development 114:787-796.


29.    Zhou, Z. and Elledge, S.J. (1992) Analysis of the DNA damage sensory pathway through the isolation and characterization of the CRT mutants, constitutive for RNR3 transcription. Genetics 131:851-866.


30.    Koff, A., Giordano, A., Desai, D., Yamashita, K., Harper, J.W., Elledge, S.J., Nishimoto, T., Morgan, D.O., Franza, R., and Roberts, J.M. (1992) Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle.  Science 257:1689-1694.


31.    Ramer, S.W., Elledge, S.J., and Davis, R.W. (1992) Dominant genetics using a yeast genomic library under the control of a strong inducible promoter. Proc. Natl. Acad. Sci. USA 89:11589-11593.


32.    Durfee, T., Becherer, K., Chen, P., Yeh, S., Yang, Y., Kilburn, A., Lee, W., and Elledge, S.J. (1993) The Retinoblastoma Protein Associates with the Protein Phosphatase Type 1 Catalytic Subunit. Genes & Development 7:555-569.


33.    Leach, F.S., Elledge, S.J., Scherr, C.J., Wilson, J.K.V., Markowitz, S., Kinzler, K.W., and Vogelstein, B. (1993) Amplification of Cyclin Genes in Colorectal Carcinomas, Cancer Research 53:1986-1989.


34.    Zhang, X., Settleman, J., Kyriakis, J. M., Takeuchi-Suzuki, E., Elledge, S. J. Marshall, M. S., Bruder, J. T., Rapp, U. R., and Avruch, J. (1993). Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1. Nature 364, 308-313.


35.    Elledge, S.J., Bai, C., and Edwards, M.C (1993) Cloning Human Genes Using cDNA Expression Libraries in S. cerevisiae. Methods 5:96-101.


36.    Elledge, S.J., Zhou, Z., Allen, J.B., and Navas, T.A. (1993) DNA damage and cell cycle regulation of ribonucleotide reductase in yeast.  BioEssays 15:1-7.


37.    Staudinger, J., Perry, W.M., Elledge, S.J., and Olson, E.N. (1993) Interactions among vertebrate helix loop helix proteins in yeast using the two hybrid system.  J. Biol. Chem. 268:4608-4611.


38.    Zhou, Z. and Elledge, S.J. (1993) DUN1 encodes a protein kinase that controls the DNA damage response in yeast.  Cell 75:1119-1127.


39.    Harper, J.W., Adami, G.,Wei, N., Keyomarsi, K., and Elledge, S.J. (1993) The p21 Cdk-interacting protein Cip1 is a Potent Inhibitor of G1 Cyclin-Dependent Kinases.  Cell,  75:805-816.


40.    Bai, C., Richman, R., and Elledge, S.J.  (1994) Human Cyclin F.  EMBO J. 13:6087-6098.


41.    Mulligan, J.T., and Elledge. S.J.  (1994) The construction and use of cDNA libraries for genetic selections.  In “Molecular Genetics of Yeast: A Practical Approach” Oxford University Press, Oxford, U.K.  pp. 65-81.


42.    Elledge, S.J., Zhou, Z., Allen, J.B., Navas, T.A., and W.J. Jones (1994) DNA damage and cell cycle regulation  in S. cerevisiae.  In “The Cell Cycle: Regulators, Targets, and Clinical Applications” (Ed. V. Hu) Plenum Publishing Corp., pp.163-166.


43.    Pearlman, J.A., Powser, P.A., Elledge, S.J. and Caskey, C.T. (1994) Troponin T is capable of binding dystrophin via a leucine zipper.  FEBS Letters. 354:183-186.


44.    Li, L., Elledge, S.J., Peterson, C.A., Bales, E.S., Legerski, R.J. (1994) Specific association between the human DNA repair factors Xpa and Ercc1.  Proc. Natl. Acad. Sci. USA 91:5012-5016.


45.    El-Deiry, W.S., Harper, J.W., O,Connor, P.M., Velculescu, V, Canman, C.E., Jackman, J., Pietenpol, J., Burell, M., Hill, D.E., Mercer, W.E., Kastan, M.B., Kohn, K.W., Elledge, S.J., Kinzler, K.W., and Vogelstein, B. (1994) WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.  Cancer Research 54:1169-1174.


46.    Helps, N.R., Street, A.J., Elledge, S.J., and Cohen, P.T.W. (1994) Cloning of the complete coding region for human protein phosphatase inhibitor 2 using the two hybrid system and expression of inhibitor-2 in E. coli.  FEBS Lett. 340:93-98.


47.    Allen, J.B. and Elledge, S.J.  (1994)  A Family of Vectors that Facilitate Transposon and Insertional Mutagenesis of Cloned Genes in Yeast.  Yeast 10:1267-1272.


48.    Dulic, V., Kaufmann, K., Wilson, S., Tlsty, T., Lees, E., Harper, J.W., Elledge, S.J., and Reed, S.  (1994)  p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest.  Cell 76:1013-1023.


49.    Allen, J.B., Zhou, Z. Siede, W., Friedberg, E.C. and Elledge, S.J.  (1994) The SAD1/RAD53 Protein Kinase Controls Multiple Cell Cycle Checkpoints and DNA Damage Induced Transcription in Yeast.  Genes & Development 8:2401-2415.


50.    Elledge, S.J. and Harper, J.W. (1994) Cdk inhibitors: on the threshold of checkpoints and development.  Current Opinion in Cell Biology 6:847-852.


51.    Durfee, T. Mancini,M.A., Jones, D., Elledge, S.J., and Lee, W.H. (1994) The amino-terminal region of the retinoblastoma gene product binds a novel nuclear matrix protein that localizes to RNA processing domains.  J. Cell Biol. 127:609-622.


52.    Flores-Rozas, H., Kelman, Z., Dean, F.B., Pan, Z., Harper, J.W., Elledge, S.J., O’Donnell, M., and Hurwitz, J.  (1994) Cdk-interacting Protein-1 (Cip1, WAF1) directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase d holoenzyme.  Proc. Natl. Acad. Sci. USA 91:8655-8659.


53.    Inouye, C., Remondelli, P., Karin, M., and Elledge, S.J. (1994) Isolation of a cDNA Encoding a Metal Response Element Binding Protein Using a Novel Expression Cloning Procedure: The One Hybrid System.  DNA and Cell Biology 13:731-742.


54.    S. Elledge. (1995) Complementation Cloning in  “Molecular cloning:  A laboratory manual 3rd ed. (Cold Spring Harbor, New York:  Cold Spring Harbor Laboratory Press). Eds.Sambrook, J., Fritsch, E.F., and Maniatis, T.


55.    Staudinger, J., Zhou, J. Burgess, R., Elledge, S.J., and Olson, E.N. (1995) PICK1: A perinuclear binding protein and substrate for protein kinase C isolated by the two hybrid system.  J. Cell Biol. 128:263-271.


56.    Lee, T.H., Elledge, S.J., and Butel, J.S. (1995) Hepatitus B Virus X Protein Interacts with a Probable Cellular DNA Repair Protein. J. Virology 69:1107-1114.


57.    Harper, J.W. and Elledge, S.J. (1995) CDK2 in Protein Kinase Factsbook.  (S. Hanks ed.) Academic Press, NY, NY pp.188-190.


58.    Navas, T., Zhou, Z., and Elledge, S.J. (1995) DNA polymerase epsilon links the DNA replication machinery to the S phase checkpoint.  Cell 80:29-39.


59.    Parker, S.B., Eichele, G., Zhang, P., Rawls, A., Sands, A.T., Bradley, A., Olson, E.N., Harper, J.W., and Elledge, S.J. (1995) p53-Independent Expression of p21Cip1 in Muscle and Other Terminally Differentiating Cells.  Science 267:1024-1027.


60.    Harper, J.W., Elledge, S.J., Keyomarsi, K., Dynlacht, B., Tsai, L.-H., Zhang, P., Dobrowolski, S., Bai, C., Connell-Crowley, L., Swindell, E., Fox, M.P., and Wei, N. (1995) Inhibition of cyclin-dependent kinases by p21.  Mol. Biol. Cell. 6:387-400.


61.    Matsuoka, S., Edwards, M., Bai, C., Parker, S., Zhang, P., Baldini, A., Harper, J.W., and S.J. Elledge. (1995)  p57KIP2, a structurally distinct member of the p21CIP1 Cdk-inhibitor family, is a candidate tumor suppressor gene.  Genes & Development 9:650-662.


62.    Sanchez, Y. and S.J. Elledge.  (1995) Stopped for Repairs.  BioEssays 17:545-548.


63.    Bai, C. and S.J. Elledge.  (1995) Cloning Using the Two-hybrid System.  Methods in Enzymol. 273:331-347.


64.    Ouspenski, I.I., Mueller, U. W. Matynia,  A., Sazer, S., Elledge, S. J.  and B. R. Brinkley. (1995) Ran-binding protein-1 is an essential component of the Ran/RCC1 molecular switch system in budding yeast.  J. Biol. Chem. 270:1975-1978.


65.    Sicinski, P., Donaher, J.L., Parker, S.B., Li, T., Fazeli, A., Gardner, H., Haslam, S.Z., Bronson, R.S., Elledge S.J., and R.A. Weinberg. (1995)  Cyclin D1 provides a link between development and oncogenesis in the retina and the breast. Cell 82:621-630.


66.    Deng, C., Zhang, P., Harper, J.W., Elledge, S.J., and Leder, P.J. (1995) Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell 82:675-684.


67.    Hoovers, J., Kalikan, L., Johnson, L., Alders, M., Redeker, B., Law, D., Bliek, J., Steenman, M., Benedict, M., Weigant, J., Cremer, T., Miller, P., Schlessinger, D., Edwards, M., Elledge, S.J., Ivens, A., Westerfield, A., Little, P., Mannens, M., and Feinberg A.P. (1995) Multiple genetic loci within 11p15.5 defined by Beckwith-Weidemann Syndrome rearrangement breakpoints and subchromosomal transferable fragments.  Proc. Natl. Acad. Sci. USA 92:12456-12460.


68.    Allen, J.B., Walberg, M.W., Edwards, M.C., and Elledge, S.J. (1995) Finding Prospective Partners in the Library: The Two Hybrid System and Phage Display Find a Match.  Trends Biochem. Sci . 20:511-516.


69.    Tian, Q., Taupin, J-L., Elledge, S.J., Robertson, M., and Anderson, P.A. (1995) Fas-activated Serine/Threonine Kinase (FAST) Phosphorylates TIA-1 during Fas-mediated Apoptosis. J. Exp. Med. 182:865-874.


70.    Helps, N.R., Barker, H.M., Elledge, S.J., and Cohen, P.T.W. (1995) Protein Phosphatase 1 interacts with p53BP2, a protein which binds to the tumor suppressor p53.  FEBS Letters 377:295-300.


71.    Eastham, J.A., Hall, S.J., Sehgal, I., Wang, J., Timme, T.L., Yang, G., Connell-Crowely, L., Elledge, S.J., Zhang, W.-W., Harper, J.W., and Thompson, T.C. (1995) In vivo Gene Therapy with p53 or p21 adenovirus for Prostate Cancer.  Cancer. Res. 55:5151-5155.


72.    Matsuoka, S., Thompson, J.S., Edwards, M.C., Barletta, J.M., Grundy, P., Kalikin, L.M.,  Harper, J.W., Elledge, S.J., and Feinberg, A.P. (1996) Imprinting of the gene encoding a human cyclin-dependent kinase inhibitor, p57KIP2, on chromosome 11p15. Proc. Natl. Acad. Sci. USA . 93:3026-3030.


73.    Sanchez, Y., Desany, B.A., Jones, W.J., Liu, Q., Wang, B., and Elledge, S.J. (1996) Regulation of RAD53 by the ATM-like Kinases MEC1 and TEL1 in Yeast Cell Cycle Checkpoint Pathways.  Science 271:357-360.


74.    Harper, J.W., and Elledge, S.J. (1996) Cdk Inhibitors in Development and Cancer Current Opinion in Genetics and Development 6:56-64.


75.    Navas, T., Sanchez, Y. and Elledge, S.J. (1996) RAD9 and DNA polymerase epsilon form parallel sensory branches for transducing the DNA damage checkpoint signal in S. cerevisiae Genes & Development 10:2632-2643.


76.    Kondo, M., Matsuoka, S., Uchida, K., Osada, H., Nagatake, M., Takagi, K., Harper, J.W., Takahashi, T., Elledge, S.J., and Takahashi, T. (1996)  Selective maternal allele loss in human lung cancers of the maternally expressed p57KIP2 gene at 11p15.5.  Oncogene 12:1365-1368.


77.    Bai, C., Sen, P., Hofmann, K., Ma, L., Goebl, M., Harper, J.W. and Elledge, S.J. (1996) SKP1 Connects Cell Cycle Regulators to the Ubiquitin Proteolysis Machinery Through a Novel Motif, the F-box.  Cell 86:263-274.


78.    Elledge, S.J., Winston, J., and Harper, J.W. (1996) A question of balance: the role of cyclin-kinase inhibitors in development and tumorigenesis. Trends Cell Biol. 6:388-392.


79.    Siede, W., Allen, J.B., Elledge, S.J., and Friedberg, E.C. (1996) The S. cerevisiae MEC1 gene, which encodes a homolog of the human ATM gene product, is required for G1 arrest following radiation treatment. J. Bacteriol. 178:5841-5843.


80.    Sicinski, P., Donaher, J.L., Geng, Y., Parker, S.B., Gardner, H., Park, M.Y.,  Robker, R.L., Richards, J.S., McGinnis, L.K., Biggers, J.D., Eppig, J.J., Bronson, R.T., Elledge, S.J. and Weinberg, R.A.  (1996) Cyclin D2 is an FSH-Responsive Gene Involved in Gonadal Cell Proliferation and Oncogenesis.  Nature 384:470-474.


81.    Lin, R., Allis, C.D, and Elledge, S.J. (1996) PAT1, An Evolutionarily Conserved Acetyltransferase Homolog, Is Required For Multiple Steps in the Cell Cycle.  Genes Cells 1:923-942.


82.    Elledge, S.J. (1996) Cell Cycle Checkpoints: Preventing an Identity Crisis.  Science 274:1664-1672.


83.    Dynlacht, B.D., Ngwu, C., Winston, J., Swindell, E.C., Elledge, S.J., Harlow, E., and Harper, J.W. (1997) Purification and analysis of CIP/KIP proteins. Methods in Enzymology 283:230-244.


84.    Aronheim, A., Hennemann, H., Elledge, S.J., and Karin, M. (1997)  Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions. Mol. Cell. Biol. 17:3094-3102.


85.    Zhang, P., Liegeois, N.J., Wong, C., Hou, H., Finegold, M., Silverman, A., Harper, J.W.,  DePinho, R.A., and Elledge, S. J. (1997)  Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith-Wiedeman Syndrome.  Nature 387:151-158.


86.    Edwards, M.C., Liegeois, N.J., Horecka, J., DePinho, R.A., Sprague, G.F. Jr., Tyers, M., and Elledge, S.J. (1997)  Human CPR (Cell cycle Progression Restoration) genes impart a Far- phenotype on yeast cells. Genetics147:1063-1076.


87.    Huang, M., and Elledge, S.J. (1997) Identification of RNR4, Encoding a second essential small subunit of ribonucleotide reductase in Saccharomyces cerevisiaeMol. Cell. Biol. 17:6105-6113.


88.    Sanchez, Y., Wong, C.,Thoma, R.S., Richman, R.,Wu, Z., Piwnica-Worms, H, Elledge, S.J. (1997) Conservation of The Chk1 Checkpoint Pathway in Mammals: Linkage of DNA Damage to Cdk Regulation via Cdc25. Science 277: 1497-1501.


89.    Bai, C. and Elledge, S.J.  (1997)  Gene Identification using yeast two-hybrid system.  Methods in Enzymol. 283:141-156.


90.    Skowyra, D., Craig, K., Tyers, M., Elledge, S.J., and Harper, J.W.  (1997)  F-box proteins are components of E3 complexes and act as receptors to recruit phosphorylated substrates for ubiquitnation.  Cell 91:209-219.


91.    Lee, P., DeBaun, M., Randhawa, G., Reichard, B., Elledge, S.J., and Feinberg, A.P. (1997) Low frequency of p57KIP2 mutations in Beckwith-Wiedeman Syndrome.  Amer. J. Human Genet. 61:304-309.


92.    Sanchez, Y., Zhou, Z., Huang, M., Kemp, B.E., and Elledge, S.J. (1997) Analysis of Budding Yeast Kinases Controlled by DNA Damage.  Methods in Enzymol.  283:398-410.


93.    Bai, C. and Elledge, S.J.  (1997)  Searching for Interacting Proteins Using the Two-hybrid System I.  In:  The Yeast Two-Hybrid System, P. Bartel, S. Fields, eds., Oxford University Press, Oxford, U.K., pp. 11-28.


94.    Bachant, J., and Elledge, S.J.  (1997) Regulatory Networks that Control DNA Damage Inducible Genes in Saccharomyces cerevisiae.  In DNA Damage and Repair: Biochemistry, Genetics and Cell Biology, Vol. 1. J. Nicoloff, M. Hoekstra eds., Humana Press, Totowa, N.J., pp. 383-410.


95.    Connell-Crowley, L., Elledge, S.J., and Harper, J.W. (1998) G1 cyclin-dependent kinases are sufficient to initiate DNA synthesis in quiescent human fibroblasts.  Current Biology 8:65-68.


96.    Elledge, S.J. (1998) Mitotic Arrest: Mad2 prevents sleepy from waking-up the APC.  Science 279:999-1000.


97.    Harper, J.W. and Elledge, S.J. (1998) The role of Cdk7 in Cdk activation; a retro-retrospective. Genes & Development 12:285-289.


98.    Elledge, S.J. and Harper, J.W. (1998) The Role of Protein Stability in the Cell Cycle and Cancer.  Biochimica et Biophysica Acta 1377:61-70.


99.    Edwards, M.C., Wong, C. and Elledge, S.J. (1998). Human cyclin K, a novel RNA Polymerase II-associated cyclin possessing both carboxy-terminal domain kinase and CDK-activating kinase activity.  Mol. Cell Biol. 18:4291-4300.


100.  Huang, M., Zhou, Z. and Elledge, S.J. (1998) The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor.  Cell 94:595-605.


101.  Desany, B.A., Alcasabas, A.A., Bachant, J.B. and S.J. Elledge. (1998) Recovery from DNA Replicational Stress is the Essential Function of the S phase Checkpoint Pathway. Genes & Development 12:2956-2970.


102.  Liu, Q., Li, M.Z., Liebham, D., Cortez, D. and S.J. Elledge. (1998) The univector plasmid fusion system, a method for rapid construction of recombinant DNA without restriction enzymes. Current Biology 8:1300-1309.


103.  Zhang, P., Wong, C. DePinho, R.A., Harper, J.W. and S.J. Elledge. (1998) Cooperation between the Cdk Inhibitors p27KIP1 and p57KIP2 in the Control of Tissue Growth and Development. Genes and Dev. 12:3162-3167.


104.  Matsuoka, S., Huang, M. and S.J. Elledge. (1998) Linkage of ATM to Cell Cycle Regulation by the Chk2 Protein Kinase.  Science 282:1893-1897.


105.  Zhang, P., Wong, C., Finegold, M., Harper, J.W. and S.J. Elledge. (1999) p21CIP1 and p57KIP2 Control Muscle Differentiation at the Myogenin Step. Genes & Development 13: 213-224.


106.  Gomez Lahoz, E., Liegeois, N.J., Zhang, P., Engelman, J.A., Horner, J., Silverman, A., Burde, R., Roussel, M.F., Sherr, C.J., Elledge, S.J. and R.A. DePinho. (1999) Cyclin D- and E-dependent kinases and the p57(KIP2) inhibitor: cooperative interactions in vivo.  Mol. Cell. Biol. 19:353-363.


107. Wang, H. and S.J. Elledge. (1999) DRC1, DNA Replication and Checkpoint protein 1, functions with DPB11 to control DNA replication and the S phase checkpoint in S. cerevisiae. Proc. Natl. Acad. Sci. USA 96:3824-3829.


108.  Winston, J.T., Strack, P., Beer-Romero, P., Chu, C., Elledge, S.J. and J.W. Harper. (1999) The SCF-b-TRCP ubiquitin ligase complex associates specifically with phosphorylated IkB and b-catenin and stimulates IkBa ubiquitination in vitro. Genes & Development 13:270-283.


109.  Liu, Q., Li, M.Z., Liu, D., and S.J. Elledge. (2000) Rapid Construction of Recombinant DNA by the Univector Plasmid-Fusion System. Methods Enzymology 328:530-549.


110.  Skowyra, D., Koepp, D., Kamura, T., Conrad, M.,Conaway, R.C., Conaway, J.W., Elledge, S.J. and J.W. Harper. (1999) Reconstitution of G1 Cyclin Ubiquitination with complexes containing SCFGrr1 and Rbx1.  Science 284:662-665.


111.  Kamura, T., Koepp, D. Conrad, M., Skowyra, D., Moreland, R.J., Iliopoulos, O., Lane, W.S, Kaelin, W.G., Elledge, S.J., Conaway, J.W., Harper, J.W., and J.W. Conaway. (1999). Rbx1, A Component of the VHL Tumor Suppressor Complex and SCF Ubiquitin Ligase. Science 284: 657-661.


112.  Bachant, J.B. and S.J. Elledge. (1999) Mitotic Treasures in the Nucleolus.  Nature 398:757-758.


113.  Koepp, D., Harper, J.W.  and S.J. Elledge. (1999) How the cyclin became a cyclin: Regulated proteolysis in the cell cycle.  Cell 97:431-434.


114.  Kitagawa, K., Skowyra, D., Elledge, S.J., Harper, J.W., and P. Hieter. (1999) SGT1 Encodes an Essential Component of the Yeast Kinetochore Assembly Pathway and a Novel Subunit of the SCF Ubiquitin Ligase Complex. Molecular Cell 4:21-33.


115.  Cortez, D., Wang, Y., Qin, J., and S.J. Elledge (1999) Requirement of ATM-Dependent Phosphorylation of BRCA1 in the DNA Damage Response to Double-Strand Breaks.  Science 286:1162-1166.


116.  Sanchez, Y., Bachant, J., Wang, H., Hu, F., Tetzlaff, M., Lou, D., and S.J. Elledge. (1999) Control of the DNA Damage Checkpoint by Chk1 and Rad53 Protein Kinases Through Distinct Mechanisms.  Science 286: 1166-1171.


117.  Harper, J.W. and S. J.  Elledge. (1999) Skipping into the E2F1-destruction pathway Nat. Cell Biol. 1:E5-7.


118.  Winston, J.T., Koepp, D.M., Zhu, C., Elledge, S.J., and J.W. Harper. (1999) A family of mammalian F-box proteins. Curr. Biol. 9:1180-2.


119.  Caspary, T., Cleary, M.A., Perlman, E.J., Zhang, P., Elledge, S.J., and S.M. Tilghman. (1999) Oppositely imprinted genes p57(Kip2) and igf2 interact in a mouse model for Beckwith-Wiedemann syndrome. Genes & Development 13:3115-24.


120.  Ouspenski, I.I., Elledge, S.J., and B.R. Brinkley. (1999) New yeast genes important for chromosome integrity and segregation identified by dosage effects on genome stability. Nucleic Acids Res. 27:3001-8.


121.  Hirao, A., Kong, Y.. Wakeham, A., Yoshida, H., Ruland, J., Matsuoka, S., Liu, D., Elledge, S.J. and T. Mak. (2000). DNA damage-induced activation of p53 by the checkpoint kinase Chk2.  Science 287:1824-1827.


122.  Gripp, K.W., Wotton, D., Edwards, M.C., Roessler, E., Ades, L., Meinecke, P.   Richieri-Costa, A.,  Zackai, E.H., Massagué, J., Muenke, M.  and S. J. Elledge. (2000) Mutations in TGIF Cause Holoprosencephaly and link Nodal Signaling to Human Neural Axis Determination.  Nature Genetics 25:205-208.


123.  Wang, Y. , Cortez,, D., Yazdi, P., Neff, N., Elledge, S.J. and Qin, J. (2000) BASC, A Super Complex of Brca1-Associated Proteins involved in recognition and repair of Aberrant DNA Structures.  Genes & Development 14:927-39.


124.  Lozano, G. and Elledge, S.J. (2000) p53 sends nucleotides to repair DNA. Nature 404:24-25.


125.  Liu , Q, Guntuku, S., Cui, X.-S., Matsuoka, S., Cortez, D., Tamai, K., Luo, G., Sandra Carattini-Rivera, S., DeMayo, F., Bradley, A., Donehower, L. A., and S.J. Elledge. (2000) Chk1 is an essential kinase that is regulated by Atr and required for the G2/M DNA damage checkpoint.  Genes & Development 14:1448-1459.


126.  Cortez, D. and Elledge, S.J. (2000) Conducting the Mitotic Symphony. Nature 406: 354-356.


127.  Matsuoka, S. Rotman, G., Ogawa, A., Shiloh, Y. Tamai, K.and S. J. Elledge (2000) Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro. Proc. Natl. Acad. Sci. USA 97:10389-10394.


128.  Wang, Y., Hu, F. and Elledge, S.J.  (2000) The Bfa1/Bub2 GAP Complex Comprises a Universal Checkpoint Required to Prevent Mitotic Exit. Current Biol. 10:1379-82.


129.  Tibbetts, R., Cortez, D., Brumbaugh, K.M., Scully, R., Livingston, D., Elledge, S.J. and Abraham, R.T. (2000)  Functional interactions between Brca1 and the checkpoint kinase ATR during genotoxic stress. Genes & Development 14:2989-3002.


130.  Schulman, B.A., Carrano, A.C. Jeffrey, P.D., Bowen, Z., Kinnucan, E., Finnin, M.S., Elledge, S.J., Harper, J.W., Pagano M., and Pavletich, N.P. (2000) Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex.  Nature 408:381– 386.


131.  Zhou, B.B. and Elledge, S.J. (2000) The DNA Damage Response: Putting Checkpoints in Perspective.  Nature 408:433-439.


132.  Huang, M. and Elledge, S.J. (2000) The FHA Domain, a Phosphoamino Acid Binding Domain Involved in DNA Damage response Pathway.  Cold Spring Harbor Symposium on Quantitative Biology, Vol. LXV, pp. 413-421.


133.  Goldberg, A.L., Elledge, S.J. and Harper, J.W.  (2001)  The Cellular Chamber of Doom.  Scientific American, 284:68-73.


134.  Cho, R.J., Huang, M., Campbell, M.J., Dong, H., Steinmetz, L., Sapinoso, L., Hampton, G., Elledge, S.J., Davis, R.W and Lockhart, D.J.  (2001) Transcriptional regulation and function during the human cell cycle. Nat. Genet. 27:48-54.


135.  Hu, F., Alcasabas, A.A. and Elledge, S.J. (2001) Asf1 Links Rad53 to Control of Chromatin Assembly. Genes & Development 15:1061-6.


136.  Wang, H., Liu, D., Wang, Y., Qin, J. and Elledge, S.J. (2001) Pds1 Phosphorylation in Response to DNA Damage is Essential for Its DNA Damage Checkpoint Function. Genes & Development 15:1361-72.


137.  Gasch, A.P., Huang, M., Metzner, S., Botstein, D., Elledge, S.J., and Brown P.O. (2001) Genomic expression responses to DNA-damaging agents and the regulatory role of the yeast ATR homolog MEC1. Mol. Biol. Cell 12:2987-3003.


138.  Alcasabas, A.A., Osborn, A.J., Bachant, J., Hu, F., Werler, P.J.H., Bousset, K., Furuya, K., Diffley, J.F.X., Carr, A., and Elledge, S.J. (2001) Mrc1 Transduces Signals of DNA Replication Stress to Activate Rad53. Nat. Cell Biol. 3:958-965.


139.  Paull, T.T., Cortez, D., Bowers, B., Elledge, S.J. and Gellert, M. (2001) Direct Binding of DNA by Brca1. Proc. Natl. Acad. Sci. USA 98:6086-6091.


140.  Matsuoka, S., Nakagawa, T., Masuda, A., Haruki, N., Elledge S.J. and Takahashi, T. (2001) Reduced expression and impaired kinase activity of a Chk2 mutant identified in human lung cancer. Cancer Res. 61:5362-5365.


141.  Koepp, D.M., Schaefer, L.K., Ye, X., Keyomarsi, K., Chu, C., Harper, J.W., and Elledge, S.J.

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142.  Cortez, D., Guntuku, S., Qin, J., and Elledge, S.J. (2001) ATR and ATRIP: Partners in Checkpoint Signaling.  Science 294:1713-1716.


143.  Hu, F., Wang, Y., Liu, D., Li, Y., Qin, J., and Elledge, S.J. (2001) Regulation of the Bub2/Bfa1 GAP complex by Cdc5 and Cell Cycle Checkpoints.  Cell 107:655-665.


144.  Bachant, J., Alcasabas, A. and Elledge, S.J. (2002) The SUMO-1 Isopeptidase Smt4 is Linked to Centromeric Cohesion through SUMO-1 Modification of DNA Topoisomerase II.  Mol. Cell 9:1169-82.


145. Lee Zou, L. and Elledge, S.J. (2002) Sensing and Signaling DNA Damage: Roles of Rad17 and Rad9 Complexes in the Cellular Response to DNA Damage. Harvey Lecture Series 2001-2002; 97:1-15.


146.  Zou, L., Cortez, D., and Elledge, S.J. (2002) Regulation of ATR Substrate Selection by Rad17-Dependent Loading of Rad9 Complexes onto Chromatin. Genes & Development 16:198-208.


147.  Li, Y., Bachant, J., Alcasabas, A.A., and Elledge, S.J. (2002) The Mitotic Spindle is Required for Loading of the DASH Complex onto the Kinetochore.  Genes & Development 6:183-197.


148.  Weiss, R.S., Matsuoka, S., Elledge, S.J. and Leder, P. (2002) Hus1 acts upstream of Chk1 in a mammalian DNA damage response pathway. Curr. Biol. 12:73-7.


149.  Hirao, A., Cheung, A., Duncan, G., Girard, P.M., Elia, A.J., Wakeham, A., Okada, H., Sarkissian, T., Wong, J.A., Sakai, T., De Stanchina, E., Bristow, R.G., Suda, T., Lowe, S.W., Jeggo, P.A., Elledge, S.J., Mak, T.W. (2002).  Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner.  Mol. Cell Biol. 22:6521-32.


150.  Zhang, P., Li, M. Z. and Elledge, S. J. (2002) Towards Genetic Genome Projects: Genomic Library Screening and Gene Targeting Vector Construction in a Single Step.  Nature Genetics 30:31-39.


151.  Elledge, S.J. and Amon, A. (2002)  The BRCA1 Suppressor Hypothesis: An explanation for the

tissue-specific tumor development in BRCA1 patients. Cancer Cell 1:129-132.


152.  Zheng, N., Schulman, B.A., Miller, J.J., Song, L., Jeffery, P.D., Wang, P., Chu, C., Koepp, D.E., Elledge, S.J., Pagano, M., Conaway, R.C., Conaway, J.W., Harper, J.W., and Pavletich, N.P. (2002) Structure of the Cul1-Rbx1-Skp1-F box-Skp2 SCF ubiquitin ligase complex.  Nature 416:703 – 709.


153.  Wang H, and Elledge SJ. (2002) Genetic and Physical Interactions Between DPB11 and DDC1 in the Yeast DNA Damage Response Pathway.  Genetics 160:1295-1304.


154.  Stewart, G. and Elledge, S.J. (2002) The two faces of BRCA2, a FANCtastic discovery.  Mol. Cell 10:2-4.


155.  Wilson, J. H. and Elledge, S. J.  (2002)  BRCA2 Enters the Fray.  Science 297:1822-1823.


156.  Wang, B., Matsuoka, S. , Carpenter, P. B., and Elledge, S.J. (2002) 53BP1, a Mediator of the DNA Damage Checkpoint.  Science 298:1435-1438.


157.  Osborn, A.J., Elledge, S.J. and Zou, L. (2002) Checking on the Fork: The DNA Replication Stress Response Pathway.  Trends Cell Biol. 12:509-16.


158.  Hu, F., and Elledge, S.J. (2002)  Bub2 is a cell cycle regulated phospho-protein controlled by multiple checkpoints.  Cell Cycle 1:351-5.


159.  Wang, Y., Shirogane, T., Harper, J. W., and Elledge, S.J. (2003) Exit from Exit: Resetting the Cell Cycle Through AMEN Inhibition of G-protein Signaling.  Cell 112:697-709.


160.  Stewart, G.S., Wang, B., Bignell, C.R., Taylor, A.M.R. and Elledge, S.J. (2003) MDC1 is a mediator of the mammalian DNA damage checkpoint.  Nature 421:961-6.


161.  Lin S.-Y. and Stephen J. Elledge (2003) Multiple Tumor Suppressor Pathways Negatively Regulate Telomerase. Cell 113:881-889.


162.  Morales, J.C., Xia, Z., Lu, T., Aldrich, M.B., Wang, B., Rosales, C., Kellems, R.E., Hittelman, W.N., Elledge, S.J. and Carpenter, P.B. (2003) Role for the BRCT protein 53BP1 in maintaining genomic stability. J. Biol. Chem. 278:14971-7.


163.  Wang, X., Zou, L., Zheng, H., Wei, Q., Elledge, S.J. and Li, L. (2003) Genomic instability and endoreduplication triggered by RAD17 deletion. Genes Dev. 17:965-70.


164.  Li, Y. and Elledge,  SJ. (2003) The DASH Complex Component Ask1 Is a Cell Cycle-Regulated Cdk Substrate in Saccharomyces cerevisiae.  Cell Cycle. 2:143-8.


165.  Osborn, A.J. and Elledge, S.J. (2003) Mrc1 is a Replication Fork Component Whose Phosphorylation in Response to DNA Replication Stress Activates Rad53. Genes and Dev. 17:1755-67.


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167. Bernstein, E., Kim, S.Y., Carmell, M.A., Murchison, E.P., Alcorn, H., Li, M.Z., Mills, A.A., Elledge, S.J., Anderson, K.V., Hannon, G.J. (2003) Dicer is essential for mouse development. Nat. Genet. 35:215-7.


168.  Xu, L., Wei, Y., Reboul, J., Vaglio, P., Shin, T.H., Vidal, M., Elledge, S.J., Harper, J.W. (2003) BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature. 425:316-21.


169.  Zou, L. Liu, D. and Elledge, S.J. (2003) RPA–mediated recruitment and activation of Rad17 complexes. Proc. Natl. Acad. Sci. USA. 100:13827-32.


170.  Jin, J., Shirogane, T., Xu, L., Nalepa, G., Qin, J., Elledge, S.J. and J.W. Harper. (2003) SCF{beta}-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase. Genes and Dev. 17:3062-3074.


171.  Paddison, P.J., Silva, J.M., Conklin, D.S., Schlabach, M., Li, M., Gno, L., Balija, V., O’Shaughnessy, A., Scobie, K., Aruleba , S., Chan, K., Thomas Westbrook, T., Sachidanandam, R. McCombie , W.R., Elledge, S.J. and Hannon, G.J. (2004) A resource for large-scale RNAi based screens in mammals.  Nature 428:427-31.


172.  Tetzlaff, M.T., Bai, C., Finegold, M., Wilson, J,. Harper, J.W., Mahon, K.A. and Elledge SJ. (2004) Cyclin F disruption compromises placental development and affects normal cell cycle execution. Mol Cell Biol. 24:2487-98.


173.  Tetzlaff, M.T,. Yu, W., Li, M,. Zhang, P., Finegold, M., Mahon, K., Harper, J.W., Schwartz, R.J. and Elledge S.J. (2004) Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein. Proc. Natl. Acad. Sci. U. S. A. 101:3338-45.


174.  Lam, M.H., Liu, Q., Elledge, S.J. and Rosen, J.M. (2004) Chk1 is haploinsufficient for multiple functions critical to tumor suppression. Cancer Cell 6:45-59.


175.  Cortez, D., Glick, G. and Elledge, S.J.  (2004) Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases.  Proc. Natl. Acad. Sci U. S. A.  101:10078-10083.


176.  Lin SY, Li K, Stewart GS, Elledge SJ. (2004) Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation. Proc. Natl. Acad. Sci. U. S. A. 101:6484-6489.


177.  Ye, X., Nalepa, G., Welcker, M., Kessler, B., Spooner, E., Qin, J., Elledge, S.J., Clurman B.E., Harper, J.W. (2004) Recognition of phosphodegron motifs in human cyclin E by the SCFFbw7 ubiquitin ligase. J. Biol. Chem. 279:50110-9.


178.  Li, J. Li, Y.and Elledge, S.J. (2004) Genetic analysis of the kinetochore DASH complex reveals an antagonistic relationship with the Ras/PKA pathway and a novel subunit required for Ask1 association.  Mol. Cell. Biol. 25:767-78.


179.  Jin, J., Cardozo, T., Lovering, R,.C., Elledge, S.J., Pagano, M., Harper, J.W. (2004) Systematic analysis and nomenclature of mammalian F-box proteins. Genes Dev.  18:2573-80.


180.  Li, M.Z. and Elledge, S.J. (2005) MAGIC: An in vivo genetic method for the rapid construction of recombinant DNA molecules. Nat. Gen. 37:311-9.


181.  Westbrook, T.F., Martin, E.S., Schlabach, M.R., Leng, Y., Liang, A.C., Feng, B., Zhao, J.J., Roberts, T.M., Mandel, G., Hannon, G., DePinho, R., Chin, L., and S.J. Elledge (2005) A Genetic Screen for Candidate Tumor Suppressors Identifies REST.  Cell 121:837-48.


182.  Stegmeier, F., Hu, G., Rickles, R.J., Hannon, G.J. and Elledge, S.J. (2005) A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells. Proc. Natl. Acad. Sci. USA. 102:13212-7.


183.  Silva, J.M., Li, M.Z., Chang, K., Ge, W., Golding, M.C., Rickles, R.J., Siolas, D., Hu, G., Paddison, P.J., Schlabach, M.R., Sheth, N., Bradshaw, J., Burchard, J., Kulkarni, A., Cavet, G., Sachidanandam, R., McCombie, W.R., Cleary, M.A., Elledge,  S.J., Hannon, G.J. (2005) Second-generation shRNA libraries covering the mouse and human genomes. Nat. Genet. 37:1281-8.


184.  Lin, S.Y., Rai, R., Li, K., Xu, Z.X. and Elledge, S.J. (2005) BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly. Proc. Natl. Acad. Sci. USA 102:15105-9.


185.  Elledge,  S.J. and Hannon, G.J. (2005)  An open letter to cancer researchers. Science.310:439-41.


186.  Adams. M.M., Wang, B., Xia, Z., Morales, J.C., Lu, X., Donehower, L.A., Bochar, D.A., Elledge, S.J., Carpenter, P.B. (2005) 53BP1 Oligomerization is Independent of its Methylation by PRMT1. Cell Cycle. 4:1854-61.


187.  Turnell, A.S., Stewart, G.S., Grand, R.J., Rookes, S.M., Martin, A., Yamano, H., Elledge, S.J., Gallimore, P.H. (2005) The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression. Nature. 438:690-5.


188.  Lee,  Y.D. and S.J. Elledge. (2006) Control of ribonucleotide reductase localization through an

anchoring mechanism involving Wtm1. Genes Dev. 20:334-44. system for single-copy polymerase II-regulated RNA interference in mammalian cells. Proc. Natl. Acad. Sci. USA. 102:13212-7.


189.  Cao, L., Kim, S., Xiao, C., Wang, R.H., Coumoul, X., Wang, X., Li, W.M., Xu, X.L., De Soto, J.A., Takai, H., Mai, S., Elledge, S.J., Motoyama, N., Deng, C.X. (2006) ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency.  EMBO J. 25:2167-77.


190.  Westbrook, T.F., Stegmeier, F. and Elledge SJ. (2005) Dissecting cancer pathways and vulnerabilities with RNAi. Cold Spring Harb Symp Quant Biol. 70:435-44.


191.  Wang, X., Zou, L., Lu, T., Bao, S., Hurov, K.E., Hittelman, W.N., Elledge, S.J. and Li, L. (2006)  Rad17 phosphorylation is required for claspin recruitment and Chk1 activation in response to replication stress. Mol Cell. 23:331-41.


192.  Chang, K., Elledge, S.J. and Hannon, G.J. (2006) Lessons from Nature: microRNA-based shRNA libraries. Nature Methods. 3:707-14.


193.  Zhang, D., Zaugg, K., Mak, T.W. and Elledge, S. J. (2006) A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response. Cell, 12:529-42.


194.  Chou,  D.M. and Elledge, S.J. (2006) Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function. Proc. Natl. Acad. Sci. U.S.A. 103:18143-7.


195.  Li, M.Z. and Elledge, S.J. (2007) Harnessing homologous recombination in vitro to generate recombinant DNA via SLIC. Nature Methods. 4:251-6.


196.  Zaugg, K., Su, Y.W., Reilly, P.T., Moolani, Y., Cheung, C.C., Hakem, R., Hirao, A.,  Liu, Q., Elledge, S.J., and Mak, T.W. (2007) Cross-talk between Chk1 and Chk2 in double-mutant thymocytes. Proc. Natl. Acad. Sci. U.S.A. 104:3805-10.


197.  Smogorzewska, A., Matsuoka, S., Vinciguerra, P., McDonald, E.R. 3rd, Hurov, K.E., Luo, J., Ballif, B.A., Gygi, S.P., Hofmann, K., D’Andrea, A.D., Elledge, S.J. (2007)  Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair. Cell. 129:289-301.


198.  Draviam, V.M., Stegmeier, F., Nalepa, G., Sowa, M.E., Chen, J., Liang, A., Hannon, G.J., Sorger, P.K., Harper, J.W. and Elledge, S.J. (2007)A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling. Nat. Cell. Biol. 9:556-64.


199.  Stegmeier, F., Rape, M., Draviam, V.M., Nalepa, G, Sowa, M.E., Ang, X.L, McDonald, E.R. 3rd, Li, M.Z, Hannon, G.J., Sorger, P.K., Kirschner, M.W., Harper, J.W., Elledge, S.J. (2007) Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature 446:876-81.


200.  Matsuoka, S., Ballif, B.A., Smogorzewska, A., McDonald, E.R. 3rd, Hurov, K.E., Luo, J., Bakalarski, C.E., Zhao, Z., Solimini, N., Lerenthal, Y., Shiloh, Y., Gygi, S.P. and Elledge, S.J. (2007) ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.  Science. 316:1160-6.


201.  Wang, B., Matsuoka, S., Ballif, B.A., Zhang, D., Smogorzewska, A., Gygi, S.P. and Elledge, S.J. (2007) Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response.  Science. 316:1194-8.


202.  Stegmeier, F, Sowa, M.E., Nalepa, G., Gygi, S.P., Harper, J.W. and Elledge, S.J. (2007) The

tumor suppressor CYLD regulates entry into mitosis. Proc. Natl. Acad. Sci U.S.A. 104:8869-74.


203.  Popov, N., Wanzel, M., Madiredjo, M., Zhang, D., Beijersbergen, R., Bernards, R., Moll, R., Elledge, S.J., Eilers, M.   (2007) The ubiquitin-specific protease USP28 is required for MYC stability. Nat Cell Biol. 9:765-74.


204.  Solimini, N.L., Luo, J., Elledge, S.J. (2007) Non-oncogene addiction and the stress phenotype of cancer cells. Cell. 130:986-8.


205.  Schlabach, M.R., Luo, J., Solimini, N.L., Hu, G., Xu, Q.,  Li, M.Z., Zhao, Z., Smogorzewska, A., Sowa, M.E., Ang, X.L., Westbrook, T.F., Liang, A., Chang, K., Hackett, J.A., Harper, W.J., Hannon, G.J., and Elledge, S.J. (2008) Cancer Proliferation Gene Discovery Through Functional Genomics. (2008) Science. 319:620-4.


206.  Silva, J.M., Marran, K., Parker, J.S., Silva, J., Golding. M., Schlabach, M.R., Elledge, S.J., Hannon, G.J., Chang, K. (2008) Profiling essential genes in human mammary cells by multiplex RNAi screening. Science. 319:617-20.


207.  Brass, A.L., Dykxhoorn, D.M., Benita, Y., Yan, N., Engelman, A., Xavier, R.J., Lieberman, J., and Elledge, S.J.  (2008)  Identification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen.  Science. 319:921-6


208.  Westbrook, T.F., Hu, G., Ang, X.L., Mulligan, P., Pavlova, N.N., Liang, A., Leng, Y., Maehr, R., Shi, Y., Harper, W.J., and Elledge, S.J.  (2008) SCF-bTRCP Controls Oncogenic Transformation and Neural Differentiation Through REST Degradation.  Nature. 452:370-4.


209.  Harper J.W., Elledge S.J. (2007) The DNA damage response: ten years after. Mol. Cell. 28:739-45.


210.  Dephoure, N., Zhou, C., Villén, J., Beausoleil, S.A., Bakalarski, C.E., Elledge S.J., Gygi S.P. (2008) A quantitative atlas of mitotic phosphorylation.  Proc. Natl. Acad. Sci. U.S.A. 105:10762-7.


211.  Wang B., Elledge S.J. (2007) Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage. Proc. Natl. Acad. Sci. U.S.A.  104:20759-63.


212.  Burrows, A.E., Elledge, S.J. (2008) How ATR turns on: TopBP1 goes on ATRIP with ATR.  Genes and Dev. 22:1416-21.


213.  Luo, J., Elledge, S.J. (2008) Cancer: Deconstructing Oncogenesis. (2008)  Nature 453:995-996.


214.  Krishnan, M.N., Ng, A., Sukumaran, B., Gilfoy, F.D., Uchil, P.D., Sultana, H., Brass, A.L., Adametz, R., Tsui, M., Qian, F., Montgomery, R.R., Lev, S., Mason, P.W., Koski, R.A., Elledge, S.J., Xavier, R.J., Agaisse, H., Fikrig, E. (2008) RNA interference screen for human genes associated with West Nile Virus infection. Nature. 455:242-5.


215.  Li, J., Tetzlaff, M.T., Elledge, S.J., (2008) Identification of MSA1, a cell cycle-regulated, dosage suppressor of drc1/sld2 and dpb11 mutants. Cell Cycle, 7(21):3388-98.


216.  Lee, Y.D., Wang, J., Stubbe, J.A., Elledge, S.J. (2008) Dif1 is a DNA Damage Regulated Facilitator of Nuclear Import for Ribonucleotide Reductase. Mol. Cell. 32:70-80.


217.  Yen, H.S., Xu, Q. Chou, D.M., Zhao, Z., Elledge, S.J. (2008) Global protein stability profiling in mammalian cells.  Science. 322:918-23.


218.  Yen, H.S., Elledge. S.J. (2008) Identification of SCF ubiquitin ligase substrates by global protein stability profiling.  Science. 322:923-9.


219.  Collis, S.J., Ciccia, A., Deans, A.J., Horejs, Z., Martin, J.S., Maslen, S.L., Skehel, J.M., Elledge, S.J., West, S.C., Boulton, S.J. (2008) FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex. Mol. Cell. 32:313-24.


220.  Mulligan, P., Westbrook, T.F., Ottinger, M., Pavlova, N., Chang, B., Macia, E., Shi, Y.J., Barretina J., Liu, J., Howley, P.M., Elledge, S.J., Shi, Y. (2008) CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation. Mol. Cell. 32:718-26.


221.  Ishiai1, M., Kitao, H., Smogorzewska, A., Tomida, J., Kinomura, A., Uchida, E., Saber, A., Kinoshita, E., Kinoshita-Kikuta, E., Koike, T., Tashiro, S., Elledge, S.J., Takata, M. (2008) FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway. Nat. Struct. Mol. Biol. 15:1138-46.


222.  Zhang, L., Lee, S.Y., Beznoussenko, G.V., Peters, P.J., Yang, J.S., Gilbert, H.Y., Brass, A.L., Elledge, S.J., Isaacs, S.N., Moss, B., Mironov, A., Hsu, V.W. (2009) A role for the host coatomer and KDEL receptor in early vaccinia biogenesis. Proc. Natl. Acad. Sci. U.S.A. 106:163-8.


223.  Xu, Q., Schlabach, M.R., Hannon, G.J., Elledge, S.J. (2009) Design of 240,000 orthogonal 25mer DNA barcode probes. Proc. Natl. Acad. Sci. U.S.A. 106:2289-94.


224.  Naylor, M.L., Li, J.M., Osborn, A.J., Elledge, S.J. (2009) Mrc1 phosphorylation in response to DNA replication stress is required for Mec1 accumulation at the stalled fork. Proc. Natl. Acad. Sci. U.S.A. 106:12765-70.


225.  Xiao, A., Li, H., Shechter, D., Ahn, S.H., Fabrizio, L.A., Erdjument-Bromage, H., Ishibe-Murakami, S., Wang, B., Tempst, P., Hofmann, K., Patel, D.J., Elledge, S.J., Allis, C.D. (2009) WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity. Nature. 457:57-62.


226.  Wang, B., Hurov, K., Hofmann, K., Elledge, S.J. (2009) NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control. Genes and Dev. 23:729-39.


227.  Hu, G., Kim, J., Xu, Q., Leng, Y., Orkin, S.H., Elledge, S.J. (2009).  A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal. Genes and Dev. 23:837-48.


228.  Luo J., Solimini N.L., Elledge S.J. (2009) Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction. Cell, 136:823-37.


229.  Luo, J., Emanuele, M.J., Li, D., Creighton, C.J., Schlabach, M.R., Westbrook, T.F., Wong, K.-K., Elledge, S.J.  (2009) A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.  Cell 137:835-48.


230.  Svendsen, J.M. Smogorzewska, A., Sowa, M.E.,  O’Connell, B., Gygi, S.P., Elledge, S.J., Harper J.W. (2009) Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for interstrand crosslink DNA repair. Cell 138:63-77.

231.  Ciccia, A. , Bredemeyer, A.L., Sowa, ME., Terret, M.E., Jallepalli, P.V., Harper, J.W., Elledge, S.J. (2009) The SIOD disorder protein SMARCAL1 is an RPA interacting protein involved in replication fork restart. Genes Dev. 23:2415-25.


232.  Knipscheer, P., Räschle, M., Smogorzewska, A., Enoiu, M., Ho, T.V., Schärer, O.D., Elledge, S.J., Walter, J.C. (2009) The fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair. Science 326:1698-701.


233.  Brass, A.L., Huang, I.C., Benita, Y., John, S.P., Krishnan, M.N., Feeley, E.M., Ryan, B.J., Weyer, J.L., van der Weyden, L., Fikrig, E., Adams, D.J., Xavier, R.J., Farzan, M., and Elledge, S.J. (2009) The IFITM Proteins Mediate Cellular Resistance to Influenza A H1N1 Virus, West Nile Virus, and Dengue Virus. Cell 139:1243-1254.


234.  Shen, X., Do, H., Li, Y., Chung, W.H., Tomasz, M., de Winter, J.P., Xia, B., Elledge, S.J., Wang, W., Li, L. (2009) Recruitment of fanconi anemia and breast cancer proteins to DNA damage sites is differentially governed by replication. Mol. Cell 35:716-23.


235.  Li, Q., Brass, A.L., Ng, A., Hu, Z., Xavier, R.J., Liang, T.J., Elledge SJ (2009) A genome-wide genetic screen for host factors required for hepatitis C virus propagation. Proc. Natl. Acad. Sci. U.S.A. 106:16410-5.

236.  Fishler, T., Li, Y.Y., Wang, R.H., Kim, H.S., Sengupta, K., Vassilopoulos, A., Lahusen, T., Xu, X., Lee,

M.H., Liu, Q., Elledge, S.J., Ried, T., Deng, C.X. (2010) Genetic instability and mammary tumor formation in mice carrying mammary-specific disruption of Chk1 and p53. Oncogene. 29:4007-17.  PMID: 20473325


237.  Schlabach, M.R., Hu, J.K., Li, M., Elledge, S.J. (2010) Synthetic design of strong promoters. Proc.

Natl. Acad. Sci. U.S.A. 107:2538-43. PMID: 20133776


238.  Song, E.J., Werner, S.L., Neubauer, J., Stegmeier, F., Aspden, J., Rio, D., Harper, J.W., Elledge, S.J.,

Kirschner, M.W., Rape, M. (2010) The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome. Genes Dev. 24:1434-47.  PMID: 20595234


239.  Swedlow, J.R., Cotta-Ramusino, C., Elledge, S.J. (2010) Cell biology forum: Genome-wide view of mitosis. Nature.  464:684-5.   PMID: 20360724


240.  Smogorzewska, A., Desetty, R., Saito, T.T., Schlabach, M., Lach, F.P., Sowa, M.E., Clark, A.B., Kunkel, T.A., Harper, J.W., Colaiácovo, M.P., Elledge, S.J. (2010) A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair. Mol. Cell. 39:36-47. PMID: 20603073

241. Yoon, J.C., Ng, A., Kim, B.H., Bianco, A., Xavier, R.J., Elledge, S.J. (2010) Wnt signaling regulates mitochondrial physiology and insulin sensitivity. Genes Dev. 241507-18.   PMID: 20634317


242.  Stewart, G.S, Stankovic T., Byrd, P.J., Wechsler, T., Miller, E.S., Huissoon, A., Drayson, M.T., West, S.C., Elledge, S.J., Taylor, A.M. (2007) Proc. Natl. Acad. Sci. U. S. A. 104:16910-5.